Endocrine Abstracts

Objective: To describe the clinical characteristics of stroke in patients with prediabetes mellitus (pre-DM) and to compare them with DM and non-DM patient characteristics.Methods: Retrospective analysis of a prospective series of acute stroke patients. Demographic and clinical characteristics were compared among the three groups, along with outcome data. Stroke severity was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale).<p cla...

Objective: Transsphenoidal surgery (TSS) presents the treatment of choice for Cushing’s disease (CD), 95% microadenomas. Remission and recurrence rates vary dependent on tumor size, extension, adenoma visibility on magnetic resonance imaging, and neurosurgical expertise. Remission rates in the postoperative vary between 55 and 85%, with a recurrence of up to 25%. The aim of this study was to describe the rate of remission and recurrence of CD in our midst after TSS, and c...

Background: Endothelial dysfunction may have deleterious effect cardiovascular pathology in diabetic patients.Atrial natriuretic peptide (ANP) exerts beneficial effects on the cardiovascular system in part by exerting antioxidant activity. Recently it was reported that ANP is able to exert an antihypertrophic effect in myocitos at least in part due to inhibition of NADPH oxidase and superoxido generation.It seems that hyperglucemia...

Background: Primary aldosteronism is a common cause of arterial hypertension, but its underlying molecular mechanisms are unknown. K+ is a key regulator of aldosterone secretion: it interacts with physiological secretagogues of aldosterone as angiotensin II (Ang II) end endothelin-1. In vivo genetic manipulation of a widely distributed class of channels, which generate background or ‘leak’ potassium (K+) currents, the twik-related acid-se...

Objective: To evaluate the efficacy of dapagliflozin for glycemic control and progression of weight loss after stabilization with liraglutide 1.8 mg.Patients and methods: Descriptive study: patients with tipo 2 diabetes (DM-2) in treatment with metformin and liraglutide 1.8 mg, optimal metabolic control, which after stabilization in weight loss, liraglutide is suspended and dapagliflozin is added. Variables analyzed baseline and at 6 months after treatme...

Objective: To evaluate the efficacy of canagliflozin 100 mg for glycemic control and progression of weight loss after stabilization with liraglutide 1.8 mg.Patients and methods: Descriptive study: patients with type 2 diabetes (DM-2) in treatment with metformin and liraglutide 1.8 mg, optimal metabolic control, which after stabilization in weight loss, liraglutide is suspended and canagliflozin 100 mg is added. Variables analyzed baseline and at 6 months...

Objetive: The change of treatment of liraglutide 1.8 mg to dapagliflozin or canaglifonzin 100 mg in patients with optimal glycemic control and stabilization weight loss, achieves progression in weight loss and improves the metabolic control of the patient with tipo 2 diabetes (DM-2). Our objective is to evaluate if there are differences in metabolic control and progression of weight loss in patients treated with canagliflozin 100 mg or dapagliflozin.Pati...

Background: Cushing’s syndrome (CS) in medullary thyroid cancer (MTC) is rare with less than 60 cases reported. Less than 1% of MTC develop ectopic ACTH-dependent CS and this correlated with metastasis at diagnosis and poor prognosis.Case presentation: A 32-year-old male was referred to our department for suspected CS. Initial evaluation showed hypokalemia(2.4 mmol/l) and severe ACTH-dependent CS (Cortisol h8:678ng/ml; ACTH:249pg/ml; urinary free co...

Background: Lenvatinib is an oral chemotherapy for metastatic radioiodine-refractory differentiated thyroid cancer (RRDTC) which significantly improves progression free survival (PFS). It has been proved that higher rates of dose interruption or reduction of Lenvatinib have a negative impact on PFS. Patients with active cancer, such as RRDTC, have an increased risk of contracting Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and developing complications, especial...

Objective: Preclinical studies have shown that DPP-4 inhibitors (iDPP4) have beneficial effects on functional mass of beta cells and pancreatic insulin content. The aim of this study is to evaluate the efficacy of treatment with sitagliptin in monotherapy or in combination with insulin in person with type 1 diabetes (DM-1) or type LADA diabetes (DM-LADA) of recent diagnosis.Patients and methods: Descriptive study: patients with DM-1 or DM-LADA in treatme...